Monday, May 14, 2012
The weighing is the hardest part (for analysts)
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By Edward Copeland
The inimitable Samuel Clemens, better known to readers everywhere as Mark Twain, said many memorable things in his lifetime, but I've always been partial to his definition of the three types of lies. In the unlikely event that you're unfamiliar with Twain's list, his troika consisted of lies, damn lies and statistics. That statement came to my mind quite often as I watched the epic documentary project that HBO begins airing tonight, The Weight of the Nation, concerning the "obesity epidemic" in the United States. The series marks a collaboration between HBO and the Institute of Medicine in association with the Centers for Disease Control and Prevention and the National Institutes of Health and airs in four parts over the next two nights. Additionally, three episodes for families have been set for the
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Now, don't misunderstand my intentions — this review of the first two parts of The Weight of the Nation today and parts three and four on Tuesday will not end with me endorsing a diet of Big Macs and intravenous Dr Pepper. I'm not against living a healthy lifestyle or exercise — I know I'd be walking if I could — but it's important to remember that the people who assembled this project have an agenda. It might be a noble agenda, but it remains an agenda, one in which anything that might contradict the message they want to convey won't be heard. That's what bothers me. I'm not an expert in the field, so I can't thoroughly debunk and verify everything, but I'll do what I can because in the time since I first got sick, before anyone diagnosed my multiple sclerosis and the years that followed, I've experienced a lot of the health care system first-hand. As a result, I know that the biggest mistake that all health care providers as well as this documentary series make occurs when they treat every patient as if he or she comes from a cookie cutter. That's why no two sets of fingerprints are alike. No two people match up exactly and the attempt to generalize can lead to delays in correct diagnoses, misdiagnosis and risks to people's lives. Neither a country nor an individual's health can be managed by rote and, to some extent, that message underlies The Weight of the Nation. When I began having my symptoms, which started with difficulty walking, my excess poundage became the prime suspect and my primary doctor referred me to a cardiologist. Keep in mind that my blood pressure always runs in the low to normal range, my EKG results tested fine and my blood sugar level gave no indication of diabetes. He referred me to a dietitian. I changed my diet, exercised, lost 100 pounds — and the legs got worse. It took a total of two years and several doctors before we found the right neurologist who diagnosed the M.S. — and a previous doctor still tried to get me to return to re-take a test with him that had proved negative when I'd already fired him. Before I get too far off track, I do want everyone to remember this: NEVER BE AFRAID TO FIRE YOUR DOCTOR. Remember, they are the employee, you are the employer. Most of them need a swift kick in the ego now and then anyway. The whole reason I began this part of the discussion had to do with a 1988 New York Times Magazine article by Robin Marantz Henig I found about doctors rethinking the treatment of mild cases of hypertension. It wasn't so much the content of the article that I found particularly relevant, but I loved the old saying she attributes to some physicians discussing the issue because it fits here as well: "If you give a kid a hammer, every problem starts to look like a nail."
To start my review of the series' actual content on a positive note, I must admit that the behind=the-scenes team that worked on The Weight of the Nation assembled a slick, attractive product. In fact, they implement so many charts and graphics, it's as if the original USA Today had come to life. "Consequences" serves, more or less, as an overview of issues that later installments explore in more depth.
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"Consequences" stays very busy tossing out its statistics at the viewer. According to the collective weight (pun intended) of its gathered experts, more than 68 percent of American adults fit the definition of being overweight or obese. Now, neither the documentary nor the experts who appear within it offer up data to show how exactly they calculated this figure. The U.S. finds it hard to get rock-solid Census figures every 10 years and the form fails to inquired as to the weight of every member of a household (as if it could be confirmed with
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Before I begin my quest to unravel the methodology used for The National Health and Nutrition Examination Surveys (which, from here on out, despite my training to avoid using obscure acronyms, I will refer to as NHANES), I wanted to delve deeper into The Institute of Medicine, since, unlike the Centers for Disease Control and Prevention and the National Institutes of Health, isn't a branch of a larger governmental agency. According to its own web site, The Institute of Medicine describes itself as, "an independent, nonprofit organization that works outside of government to provide unbiased and authoritative advice to decision makers and the public. Established in 1970, the IOM is the health arm of the National Academy of Sciences, which was chartered under President Abraham Lincoln in 1863. Nearly 150 years later, the National Academy of Sciences has expanded into what is collectively known as the National Academies, which comprises the National Academy of Sciences*, the National Academy of Engineering, the National Research Council, and the IOM. The IOM asks and answers the nation’s most pressing questions about health and health care." I put the last sentence in bold since my blog's style places quotes in italics and the institute italicizes that sentence on its web site. Changing it to plain type just didn't underscore the emphasis it attempts to make. (*NOTE: The link to The National Academy of Sciences on the institute's page doesn't work. I had to find it by going through the link from the National Academies site.) Additionally, the Institute of Medicine boasts that, "Our aim is to help those in government and the private sector make informed health decisions by providing evidence upon which they can rely. Each year, more than 2,000 individuals, members, and nonmembers volunteer their time, knowledge, and expertise to advance the nation’s health through the work of the IOM. Many of the studies that the IOM undertakes begin as specific mandates from Congress; still others are requested by federal agencies and independent organizations. While our expert, consensus committees are vital to our advisory role, the IOM also convenes a series of forums, roundtables, and standing committees, as well as other activities, to facilitate discussion, discovery, and critical, cross-disciplinary thinking." So, though the institute isn't connected officially to the bureaucracy, much of its work gets funded by taxpayers. Unfortunately, I ran out of time to discern how much. If you click on the studies link though, you will discover
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"Data collected in NHANES comes from interviews, examinations, and laboratory tests based on blood and urine samples. There may also be measures taken in the home, such as dust or tap water collection. The source of a data item (interview, MEC*, sera**) is important for both assessment of quality of information and for determining the appropriate sampling weight to be used for producing statistical estimates. As with any data set, NHANES data are subject to sampling and non-sampling errors (including measurement error). Interview (questionnaire) data are based on self-reports and are therefore subject to non-sampling errors such as recall problems, misunderstanding of the question, and a variety of other factors. Examination data and laboratory data are subject to measurement variation and possible examiner effects. The NHANES program maintains high standards to insure non-sampling and measurement errors are minimized.…Despite the rigorous quality control standards, estimates produced from any data set are subject to sampling and non-sampling variation and interpretation of analysis must proceed accordingly. Data content and data collection protocols may change over time; this is another reason to read the documentation in order to understand any issues in comparability of data over time. Changes in methods may occur at any time and the user should not assume they have remained the same (especially in the continuous NHANES, conducted since 1999)."
— NHANES Analytic and Reporting Guidelines, Part 1 (last correction September 2006)
*Mobile Examination Centers **Subsample of stored serum of specimens from NHANES (1999–2000) tested to estimate
the prevalence and specificities of selected autoantibodies in the U.S. population in 2003-2004.
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As most of you probably realized once the word survey appeared, the statement that categorized 68 percent of Americans as overweight or obese isn't a factual one, not in the way we say, "Two plus two equals four" and know it to be true. The survey only estimates 68 percent of U.S. adults fall into the obese and overweight classifications (based on the outdated, kooky BMI, remember). However, The Weight of the Nation never presents that possibility. In this election year, polls have exploded with alarming frequency for quite some time — and it only will get worse. Despite the endless unending onslaught, even the lazy media remembers to remind us of the margin of error. The documentary never mentions the notion of sampling errors — or methodology — or any evidence that supports that figure. They pronounce that 68 percent of Americans fall into that weight class and the discussion ends and we must accept their word as gospel truth. I imagine
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"For a two-year analysis, sample size is smaller and the number of geographic units in the sample is more limited…Sample size and statistical power consideration should be used to determine if a two-year sample is sufficient for a particular analysis or if 4 (or even 6) years of the survey need to be combined to produce statistically reliable analysis."
By going by the 2007-2008 figure, The Weight of the Nation not only neglects to mention the possibility of sampling errors, it ignores the survey makers' own advice to combine samples from the previous two-year or four-year samples to paint a more accurate picture. Why do I feel I'm doing more research writing this review than some people involved in the series did? Later, in Part 3 of NHANES' Guidelines, it gets serious and pulls out bold italic again.
"Because NHANES is a complex probability sample, analytic approaches based on data from simple random sample are usually not appropriate. Ignoring the complex design can lead to biased estimates and overstated significance levels. Sample weights and the stratification and clustering of the design must be incorporated into an analysis to get proper estimates and standard errors of estimates."
Just in case you missed the point so far, they raised the size of the type again when they used it as the start of Part 5.
"5. In order to produce estimates with greater statistical reliability for demographic sub-domains and rare events, combining two or more 2-year cycles of the continuous NHANES is encouraged and strongly recommended. For two-year cycles, the sample size may be too small to produce statistically reliable estimates for very detailed demographic sub-domains (e.g. sex-age-race/ethnicity groups) or for relatively rare events. The sample design for NHANES makes it possible to combine two or more “cycles” to increase the sample size and analytic options. Each two-year cycle and any combination of those two years cycles is a nationally representative sample."
Could the CDC's National Health and Nutrition Examination Survey analytical guidelines be any clearer? The two-year sample, which The Weight of the Nation uses to yell fire in the movie theater about 68 percent of all Americans being overweight or obese, lacks a sample sizable enough to be reliable and without combining it to another cycle of NHANES surveys, the result can't be extrapolated nationally. Perhaps they tried that but the figures didn't turn out the way they wanted, especially since the CDC's NHANES report released in 2007, as reported by Gina Kolata on Nov. 27, 2007, in The New York Times, found obesity rates leveling off. Kolata wrote:
"Obesity rates in American women have leveled off and stayed steady since 1999, a long enough time for researchers to say the plateau appears to be real. And, they say, there are hints that obesity rates may be leveling off for men, too.
The researchers’ report, published online today by the Centers for Disease Control and Prevention, used data from the centers’ periodic national surveys that record actual heights and weights of a representative sample of Americans. Those surveys, according to Cynthia L. Ogden, an epidemiologist at the National Center for Health Statistics and the lead author of the new report, are the only national ones that provide such data.
Dr. Ogden said the trend for women was “great news.” Obesity rates have remained steady at about 35 percent since 1999, a long enough time to persuade her that the tide has changed. “I’m optimistic that it really is leveling off,” she said.
Men’s rates increased until 2003, when they hit 33 percent and stayed there through the 2005-6 survey. Dr. Ogden said she would like to see a few more years of data before declaring that men's rates have stopped increasing."
As much as I would like to move on, I've burrowed so deep into NHANESland that I feel I must share the actual demographic breakdown of participants in the 2007-08 survey. They go into incredible detail and include some categories that I'll admit I don't comprehend. You can click on that link for the full list, but some highlights beyond what I've sprinkled as screenshots already.
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This certainly marks a first for me. I've never had to divide a review of an HBO documentary into two parts, but I have more to say about "Consequences" (some positive things even) and the discussion of the second part, "Choices," has yet to be broached — and as a viewing experience, "Choices" ends up being the more satisfying hour.
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Labels: 10s, Boardwalk Empire, Documentary, HBO, Television, Treme, Twain
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First you should disclose: "In this post I decided to talk about things that I don't know, for which I have no expertise whatsoever and that I don't understand".
Fortunately, we have scientists doing science.
Fortunately, we have scientists doing science.
You must not have read closely because I did disclose that. I didn't question the science, I criticized them for not being open like any reputable scientist or journalist would do and cite their sources, indicate margin of errors and not state as facts figures that comes from surveys which have margin of errors just as polls do. When criticizing the BMI, I used other scientists; criticism that the index has flaws and is outdated. As I said, anyone knows that you should eat healthy and exercise, so there was no reason for the makers of the program to feel that they had to hide things that might not correspond. They assume that people can't hold contradictory ideas in their head at the same time AND they flat out ignored the analytic guidelines the CDC itself put out on how to use its figuress, I read them and understood. Either the filmmakers didn't read them, didn't understand them or chose to ignore them. Wait until later today. There is more to come. Why dud they need to play games on something like this? It's not a bad thing. They aren't trying to trick us into a war. There is no good reason except that they assume that too many people are stupid unless they twist everything to their advantage. It's sad, especially when they also highlight a real expert like Dr. Berenson who has 40 years of in-the-field research to back up what he has found.
What do you mean with "BMI is outdated"? It works, this is what matters. Not only it works, but is a simple tool that everybody can use. Calculation of body lean and fat mass? How many people with a 32 BMI you think are professional body-builders with a huge amount of lean mass accounting for this high BMI? How much do you think these extreme cases affect the general correlation between BMI and fat mass in a public health perspective? Do you really think this matters? And then, should we throw away our scales and buy Dual energy X-ray absorptiometers (I guess you can find them on Amazon)?
Besides NHANES, there are dozens of population studies carried out in the US and that include thousands of persons from different geographic areas, ethnic backgrounds essentially supporting the main message of the doc (Framingham, NOMAS, MESA, ARIC, Dallas Heart, and many more). It seems to me that your criticisms dangerously question the bottom line. Methodological problems, statistical limitations, sure these are important aspects that every respectable researcher will disclose in the medical articles they publish. But in a TV doc you cannot always go deep inside these issues. Are these flaws that hinder the main message of the show? Honestly, I don't think so.
Contradictory ideas. Okay. On EVERY possible medical subject (and non-medical for that matters), you will find contradictory data. Someone that has not been in the field for years and is not trained for this, lacks the tools to understand what are the pros and cons of a study, let alone the interpretation of the study, which may be difficult for scientists too. When comparing studies with contradictory data, one has to consider so many variables, the study design, the study sample characteristics and co-morbidities, the chosen outcome, and, very important, the statistical procedures used. The example of the obesity and mortality study that you cite is perfect. You take a study carried out in Canada! How can you compare outcomes from countries with profoundly different health care systems? Consider that obese people don't just die of obesity, but mostly of heart failure and complications of diabetes and of hypertension. Preventing death (we should actually say postponing it) in obese/overweight people means controlling the associated morbid conditions. Now consider the differences between US and Canada health care. It is very likely that the Canadian healthcare system might have played a big role in better controlling the risk of these patients especially in early stages (overweight). And there are other considerations too I.e. when you measure a variable, say BMI, at baseline, you don't really know what happens during follow-up (a consideration common to many epidemiology studies).
Long story short, you can find a study contradicting any assumption. But interpreting it is a different story.
I think that in TV show for the masses, you want to give a general message, and this they did. Plus, given the nature of how film works, I imagine that the scientist did not have complete control over it, and editors, writers and the filmmaker might have sometimes sacrificed scientific rigor to simplification. The general problem of misinformation by the media is there, however, and I recognize it. Even newspapers, when they report on clinical studies, most of the time they're inaccurate and jump to conclusions unsupported by the data.
Besides NHANES, there are dozens of population studies carried out in the US and that include thousands of persons from different geographic areas, ethnic backgrounds essentially supporting the main message of the doc (Framingham, NOMAS, MESA, ARIC, Dallas Heart, and many more). It seems to me that your criticisms dangerously question the bottom line. Methodological problems, statistical limitations, sure these are important aspects that every respectable researcher will disclose in the medical articles they publish. But in a TV doc you cannot always go deep inside these issues. Are these flaws that hinder the main message of the show? Honestly, I don't think so.
Contradictory ideas. Okay. On EVERY possible medical subject (and non-medical for that matters), you will find contradictory data. Someone that has not been in the field for years and is not trained for this, lacks the tools to understand what are the pros and cons of a study, let alone the interpretation of the study, which may be difficult for scientists too. When comparing studies with contradictory data, one has to consider so many variables, the study design, the study sample characteristics and co-morbidities, the chosen outcome, and, very important, the statistical procedures used. The example of the obesity and mortality study that you cite is perfect. You take a study carried out in Canada! How can you compare outcomes from countries with profoundly different health care systems? Consider that obese people don't just die of obesity, but mostly of heart failure and complications of diabetes and of hypertension. Preventing death (we should actually say postponing it) in obese/overweight people means controlling the associated morbid conditions. Now consider the differences between US and Canada health care. It is very likely that the Canadian healthcare system might have played a big role in better controlling the risk of these patients especially in early stages (overweight). And there are other considerations too I.e. when you measure a variable, say BMI, at baseline, you don't really know what happens during follow-up (a consideration common to many epidemiology studies).
Long story short, you can find a study contradicting any assumption. But interpreting it is a different story.
I think that in TV show for the masses, you want to give a general message, and this they did. Plus, given the nature of how film works, I imagine that the scientist did not have complete control over it, and editors, writers and the filmmaker might have sometimes sacrificed scientific rigor to simplification. The general problem of misinformation by the media is there, however, and I recognize it. Even newspapers, when they report on clinical studies, most of the time they're inaccurate and jump to conclusions unsupported by the data.
The documentary though was using those NHANES figures (not that they identified them specifically) and you can't say something is a fact when it is based on a survey which in its own guidelines states that there are sampling errors and you need to combine several years of NHANES surveys to get samples sizable enough to even get figures that you can get a conclusion. It is the same thing as a presidential poll which always shows the margin of error. They also choose to omit the CDC's figures (also from NHANES) that showed a decline in the obesity weight in adult women and a leveling off in children since 1999. The documentary was shoddy propaganda that used what fit its message and omitted things that didn't. The only part that really held up was the Bogalusa Study because the doctor had been monitoring those people over 30 years. As for BMI, there are many doctors and scientists who find that flawed and not just because of bodybuilders but in other body types as well. You won't get me defending the American health care system, but the documentary employed scare tactics and omissions when it didn't have to because it assumes that everyone is an idiot. While many Americans are idiots, it is highly unlikely they would have been watching in the first place. Just last week a British study concluded that obese people aren't inevitably at increased risk of cardiovascular disease and death. That documentary, like way too many doctors, tend to treat people as if every body is the same but we don't work that way. That's why no set of fingerprints are alike. Automatically treating people the exact same way using rote assumptions can end up causing bigger problems.
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